Can the keto diet help with depression?

Keto diet linked to significant drop in depression symptoms, study finds

A new pilot study from Ohio State University has found that following a ketogenic diet may significantly reduce symptoms of major depressive disorder (MDD) in young adults.

The trial followed 16 college students with MDD over a 10–12 week period. Researchers reported a 70% reduction in depression scores, alongside improvements in cognitive performance, overall well-being, and modest weight loss. Importantly, participants continued receiving their usual medications and counseling, making nutritional ketosis an adjunctive therapy rather than a replacement treatment.

Why keto diet may improve mental health

Experts believe the neurological benefits of ketosis could play a key role. When the body enters ketosis, the brain shifts from using glucose to using ketones as a primary energy source.

“Ketones act as signaling molecules that can improve mitochondrial function, lower inflammation, and stabilize blood sugar — all linked to mood regulation,” said Mike Kocsis, founder of Balance My Hormones (UK).

Related story: Can drinking ketones improve heart health? What experts say about the latest study

Ketones may also support the GABA neurotransmitter system, which helps regulate emotions and reduce anxiety.

Keto diet and other mental health conditions

Emerging research suggests a ketogenic diet may have therapeutic potential for bipolar disorder, ADHD, schizophrenia, Parkinson’s disease, and Alzheimer’s disease. A small 2024 study even reported complete remission of depression and anxiety symptoms in participants after 7–12 weeks of therapeutic ketosis.

Important caveats

Mental health experts caution that while these results are promising, the study was small and lacked a control group.

“A 70% drop in depression symptoms in just 10–12 weeks is impressive, but we need larger clinical trials to confirm these findings,” said therapist Shelly Dar, who specializes in mood disorders.

Related story: Keto most effective diet in short-term blood sugar control: Study

Shelly Dar stressed that keto should be used as a complement, not a substitute, for medication or therapy. Restrictive diets can also be difficult to sustain and may trigger unhealthy eating patterns in some individuals.

Safe transition to keto

If your doctor recommends trying keto as part of your mental health plan:

• Transition gradually by reducing carbs over 1–2 weeks to avoid “keto flu.”
• Focus on whole foods, non-starchy vegetables, healthy fats, and quality protein to avoid nutrient deficiencies.
• Continue regular therapy, counseling, and medication unless advised otherwise by a healthcare professional.

Holistic approach to mental health

Experts also emphasize the importance of sleep, exercise, therapy, social support, and reduced alcohol or drug use as powerful tools for improving mood and overall well-being.

---

Stay updated with Medical News Pakistan

CLICK HERE TO JOIN Medical News WhatsApp community to get the latest updates on global health guidelines, medical research, and expert insights directly on your phone.